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Fig. 6. Small, scattered cells are negative regulated by Notch. In situ hybridization shows that genes expressed in scattered cells do not colocalize with cilia (A–A′). Foxa1and CP2 are expressed throughout the embryo at tadpole stages (B, D). The uneven distribution of the cells is seen at higher magnification (B′, D′). Injection of Notchicd reduces expression of scattered cell markers in Foxa1(C, C′) and CP2 (E, E′). Slc16a3 marks scattered cells early in development (F) and its expression is also reduced by Notchicd (G). |
