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foxa4xenopus   

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Experiment details for foxa4

Peyrot SM et al. (2011) Assay

A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling.

Gene Clone Species Stages Anatomy
foxa4.L laevis NF stage 10.5 to NF stage 11 dorsal marginal zone , blastopore lip
foxa4.L laevis NF stage 14 notochord , neural plate , floor plate , neural tube

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  Fig. S6. Analysis of floor plate markers reveals two separate populations of medial floor plate. In situ hybridization for indicated markers was performed at stage 10.5–11 (A, C, E, G, I, K, M) and neurula stages (st.14—B, D, F, J, L, N, O; st.16—H, P). Prime panels (B', etc.) show transverse bisections of matching neurula stages (notochord outlined in red). Markers expressed in the organizer (marked by asterisk) at gastrula stages are expressed throughout the dorsal midline and in a narrow domain in the floor plate (A–N') at neurula stages. Netrin expression begins at early neurula stages (st.14, O) in a wider domain than early markers (O', P' compared to B'–N'). We have designated the narrow, early-forming FP the 1° MFP and the wider, later-forming FP the 2° FP.

Gene Clone Species Stages Anatomy
foxa4.L laevis NF stage 11 dorso-lateral marginal zone , dorsal marginal zone , involuting marginal zone
foxa4.L laevis NF stage 14 notochord , floor plate , neural tube

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  Fig.7. Notch signaling does not regulate gastrula midline markers or 1° MFP. Shh and plvs are markers of 1° MFP ( Fig. S6). Blockade (B, E, H) and activation (C, F, I) of Notch signaling does not affect gastrula stage expression of these markers (A–F). Expression of plvs upon perturbation of Notch signaling (G–I) looks much like that of Shh (see Fig. 2), with FP expression only mildly affected (G'–I'). (G'–I') Transverse bisections of G–I.