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frzb2xenopus   

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Experiment details for frzb2



A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1.

Gene Clone Species Stages Anatomy
frzb2.L laevis NF stage 10.5 upper blastopore lip , blastopore , dorsal
frzb2.L laevis NF stage 15 prechordal plate , endoderm , anterior
frzb2.L laevis NF stage 20 prechordal plate , intermediate mesoderm , endoderm , anterior

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  Fig. 3. Expression of crescent, frzb-1, sfrp-2 and sizzled in Xenopus embryos by whole-mount in situ hybridization. (A–D) Early gastrulae (stage 10.5) in vegetal (A,B,D) and lateral (C) view. crescent, frzb-1and sfrp-2 are expressed in the dorsal and sizzled in the ventral blastopore lip. Note an additional expression domain of sfrp-2 in the prospective dorsal neuroectoderm (ne). (E–H) Neurulae (stage 15) in dorsal (E–G) and ventral (H) view. crescent and frzb-1 transcripts are localized to anterior endoderm and prechordal plate at this stage. sfrp-2 expression is strong in the anterior neural plate (forebrain and eye field) and posterior neural plate (hindbrain and spinal cord), and is absent from the floor plate. sizzled mRNA is expressed in the ventral mesoderm (vm), including ventral blood islands, and the ventral part of the closing blastopore lip (vb). (I–L) Tailbud embryos (stage 20) in lateral view. The crescent and frzb-1 expression domains overlap in the prechordal plate and pharyngeal endoderm. Note the additional crescent domain in the pronephros (pn). sfrp-2 has a complex expression pattern in eyes, neural tube, somites and in a belt-like anterior part of the trunk. sizzled transcripts are located in ventral mesoderm and in developing heart (he).