Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Search Criteria
Gene/CloneSpeciesStageAnatomy ItemExperimenter
fzd4xenopus upper blastopore lip [+] 

Too many results?Too few results?

Experiment details for fzd4

Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis.

Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis.

Good quality Poor quality
Gene Clone Species Stages Anatomy
fzd4.L laevis NF stage 10 to NF stage 12.5 upper blastopore lip

Display additional annotations [+]
  Fig. 2. Identification of Hnf1β and Fzd4 as direct endodermal RA-target genes (A) Experimental procedure for the identification of early direct RA-target genes in the context of pancreas development. (B) Venn diagram comparing genes differentially expressed within two hours after RA-addition in the absence or presence of CHX. 46 putative direct RA-target genes were induced under both conditions. (C) RNA-sequencing results for RA-mediated Hnf1β and Fzd4 induction. The number of mapped reads two hours after the addition of RA in the presence or absence of CHX is indicated. The data result from two biological replicates with approximately 50 explants per condition. Average values are given as mean and error bars as s.e.m.. (D) WMISH for Hnf1β and Fzd4 in gastrula stage embryos. Whole embryos are depicted on the left-hand side and bisected embryos on the right-hand side. dbl, dorsal blastopore lip; e, endoderm; m, mesoderm; ne, neuro-ectoderm

Good quality Poor quality
Gene Clone Species Stages Anatomy
fzd4.L laevis NF stage 10 to NF stage 12.5 upper blastopore lip

Display additional annotations [+]
  Fig. S5. Embryonic expression of Hnf1β and Fzd4 is RA-dependent (A) WMISH for Hnf1β and Fzd4 at gastrula stage in untreated, RA-treated and cyp26a1- injected embryos. Images on the left display whole embryos (dorsal side up) and images on the right show bisected embryos (dorsal side on the right). dbl, dorsal blastopore lip; e, endoderm; m, mesoderm; ne, neuro-ectoderm. (B) Nanostring analysis of untreated, RAand BMS-treated embryos collected at indicates stages.
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556