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gdf10xenopus otic placode [+] 

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Experiment details for gdf10

Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos.

Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos.

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Gene Clone Species Stages Anatomy
gdf10.L laevis NF stage 24 otic placode
gdf10.L laevis NF stage 41 otic vesicle

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  Fig. 2. Xenopus BMP-3b and BMP-3 are expressed in dorsal ectodermal and mesodermal tissues. (A) Temporal expression analyzed by RT-PCR. BMP-3b and BMP-3 are expressed at quite low levels. After whole-mount in situ hybridization, embryos were stained for 6 days to detect xBMP-3b (B–O) and overnight for xBMP-3 (P–X). (B) Dorsal view of stage 11 embryo. Anterior region faces top. BMP-3b expression appears on dorsolateral ectoderm before neural plate is visible. Expression extends to entire neural plate until stage 12.5 (C), and localizes upon four stripes at neural plate midline and edge. (D) Expression in anterior neural plate at stage 14. Solid line indicates level of section. (E) Sagittal section of embryo. Anterior faces left. BMP-3b expression is intense in ectoderm and faint in mesoderm and endoderm. Arrows highlight BMP-3b expression in prechordal plate. (F) Lateral view of stage 24 embryo. BMP-3b is expressed in hindbrain and dorsal side of otic vesicle and neural tube. (G) BMP-3b is expressed in lips of somites and transiently in the heart. (H) Close-up view of (G). (I) Dorsal view of (H). (J) Ventral view of (H) highlights BMP-3b expression in ventricular chamber. (K) Transverse section through trunk of embryo in (H). BMP-3b is expressed in both epaxial and hypaxial dermamyotome, and dorsal half of neural tube. (L) At stage 41, expression in dermamyotome is restricted to tail. (M) Close-up of head shown in (L). BMP-3b is expressed in dorsal side of otic vesicles, optic cup, nasal pit, stomodeum, and ventral visceral pouches. (N) Dorsal view of embryo shown in (M). (O) Transverse section of embryo shown in (L). BMP-3b is expressed in head mesoderm around notochord and neural tube. (P) Vegetal view of stage 10.5 embryo. Dorsal faces top. BMP-3 is expressed in ectoderm and mesoderm. (Q) Sagittal section of embryo shown in (P). Dorsal side is to right. (R) Sagittal section of stage 15 embryo. Anterior faces left. BMP-3 is expressed in prechordal plate and chordamesoderm. (S) BMP-3 expression appears around otic vesicle at stage 24. (T) At stage 30, BMP-3 is expressed in cranial neural crest derivatives and cement gland. (U) Close up view of head shown in (T). (V) Dorsal view of (U). (W) Transverse section through head in (T). BMP-3 is localized in anterior neurocranium and dorsomedial wall of otic vesicle. (X) Transverse section through trunk. BMP-3 expression is restricted to notochord.
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