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Gene/CloneSpeciesStageAnatomy ItemExperimenter
grem1xenopus epithelium 

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Experiment details for grem1

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.

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Gene Clone Species Stages Anatomy
grem1.L laevis NF stage 29 and 30 epithelium
grem1.L laevis NF stage 37 and 38 intersomitic epithelium

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  Figure 2. Gremlin Is Expressed in the Neural Crest(A) Stage 27 embryo showing Gremlin expression in the nascent pronephric duct ([pn], arrowhead), midtrunk neural crest, and tailbud.(B) At stage 35/36, Gremlin expression expands rostrocaudally to include neural crest cells in the head, the trunk, and the fin.(C) Stage 40 embryo showing Gremlin expression following fin elongation. For (A) (C), an embryo probed with a sense control is on the bottom of each panel.(D) Section through the posterior trunk of a stage 30 embryo shows Gremlin expression in the roofplate of the neural tube and the overlying epithelium (open arrow).(E) Section through the head of a stage 38 embryo showing Gremlin expression in the mandibular mesenchymal neural crest surrounding the eye (arrow).(F) Fin section through a stage 38 embryo showing expression in mesenchymal cells.(G) Midtrunk section through a stage 38 embryo. Gremlin expression reveals the ventral migration pathways of trunk neural crest cells as they pass medially and laterally to the somite ([45, 31 and 10]). The subepithelial migration accounts for the chevron-shaped stripes of staining seen in whole mounts; Nomarski analysis of whole mounts in conjunction with horizontal sections shows that these cells migrate in the immediate vicinity of the boundaries between individual somites. Open arrowhead indicates the birthplace of neural crest cells. Closed arrowheads indicate staining of cells lining the pronephros. (rp) = roofplate, (nt) = neural tube, (no) = notochord, (so) = somite. Scale BAR= 50 um.