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Fig. 8. C-Daam1 and Daam1δDAD behave as activated form of Daam1 to mediate cell movement independent of gene induction. Embryos injected dorsally with Xdd1 (2 ng) show normal mesendoderm and neural induction but abnormal tissue localization due to gastrulation defects. This phenotype can be rescued by coexpression of C-Daam1 (100 pg of DNA) or Daam1DDAD (100 pg of DNA) coinjection but not Daam1 (1 ng of RNA) coinjection. Arrows indicate open blastopores, and the number of embryos scored is shown in each panel. |
