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hdac1xenopus animal hemisphere [+] 

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Experiment details for hdac1

Rao A and LaBonne C (2018) Assay

Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest.

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Gene Clone Species Stages Anatomy
hdac1.L laevis NF stage 2 (2-cell) animal hemisphere
hdac1.L laevis NF stage 9 animal hemisphere

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  Supplementary Figure 2. (A) In situ hybridization examining HDAC1 expression in early embryos from 2-cell to late neurula stages. (B) In situ hybridization examining neural plate border markers Msx2, Ap2, and Zic1 expression after treatment with vehicle or inhibitor (TSA- 200nM or VPA- 20mM). Embryos were treated at mid-gastrula stages (stage 11) and collected at mid-neurula stages (stage 15). (C) Explant assay examining Snail2 and FoxD3 expression in Wnt/Chordin induced explants that were treated with vehicle or inhibitor (TSA-200nM or VPA-10mM). Explants were cultured alongside sibling embryos grown until late neurula stages (stage 18). (D) Explant assay examining Snail2 and FoxD3 expression in Wnt/Chordin induced explants that were treated with vehicle (DMSO) or inhibitor (RMD – 15uM). Explants were cultured alongside sibling embryos cultured until late neurula stages (stage 18).