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Fig. 3. Repression of Xbra results in a repression of Hox genes. Nonorganiser
site injection of factors that lead to a repression of Xbra. (A–F)
Vegetal views (organiser is up) of noninjected (ni) control embryo (A) and
embryos injected with otx-2 (B), mix.1 (C), gsc (D), Sia (E) and Xbra-EnR
(F) mRNAs. All injected embryos show downregulation of Hoxd-1 on the
site of injection (arrowheads). (G–L) Non-organiser side views of
noninjected embryos (G, I, K) and Xbra-EnR-injected embryos (H, J, L).
Staining for Hoxb-4 (G, H), Hoxc-6 (I, J) and Hoxb-9 (K, L) show that these
Hox genes are also downregulated by repression of Xbra function.
Arrowheads point to the side of injection. |
