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Figure 1. Expression pattern of insm1 in endoderm. A-D: Expression of insm1 in the dorsal endoderm at NF28, NF34, NF38, and NF39, respectively. Notice expression begins as a small point in the dorsal endoderm (arrowhead) and then is found in bilateral domains at NF34 (two arrows); by NF38 expression is now present in the dorsal midline in scattered cells (outlined). Shortly thereafter expression is now found displaced to the left side of the tadpole (outlined). E,F: Isolated liver/pancreas tissue. Insm1 is detected at NF40 in a punctate manner throughout the gastrointestinal tract and in the dorsal pancreas, similar to that seen in the early endoderm. (The dotted line demarcates dorsal and ventral portions of the fused pancreas.) At later stages, expression was found throughout the entire pancreas, but still in a punctate manner. G,H: Whole guts from NF40 and NF44 tadpole. The pancreas is outlined. Expression is found in a punctate manner throughout the entire gastrointestinal tract. Dp, dorsal pancreas; vp, ventral pancreas. |
