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Gene/CloneSpeciesStageAnatomy ItemExperimenter
insm1xenopus adrenal medulla 

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Experiment details for insm1

Parlier D et al. (2009) Assay

Xenopus zinc finger transcription factor IA1 (Insm1) expression marks anteroventral noradrenergic neuron progenitors in Xenopus embryos.

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Gene Clone Species Stages Anatomy
insm1.L laevis NF stage 24 adrenal medulla
insm1.L laevis NF stage 27 to NF stage 32 adrenal medulla

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  Figure 1. Developmental expression of IA1. A-P: Dorsal views (A,B), anterior views (C,D), ventral views (E,F) and lateral views (G-P) of embryos at the indicated stages. A-C,G: IA1 is expressed in the neural plate primary neurons and in scattered cells in the anteroventral region of embryos (arrowhead). D: Xash1 is expressed at stage 12.5-13 in the anteroventral cells (arrowhead). E: Late neurula embryo double stained with IA1 and CG probes. IA1 (dark blue) punctated staining (arrowhead) is detected in front of the cement gland (light blue). F: Early tail bud embryo double stained with IA1 and Nkx-2.5 showing that IA1-positive cells are found in the developing heart field. H-O: High magnification views of the head region of early tail bud embryos stained with the indicated probes. Like IA1, Myt1, Phox2, Hand2, Hox11L2, Etr-1, CRMP-4, and TH are expressed in the anteroventral cells (arrowheads). P: HNK-1 antibody staining in early tadpole. Staining in anteroventral cells (arrowheads) is indicated. Q: Two-color double in situ hybridization of IA1 (dark blue) and epidermal keratin (light blue). Note that IA1 expressing cells are found directly below the epidermal keratin expression layer. R: One-color double in situ hybridization of IA1 (dark punctated staining) and vestigial like-4 (light uniform staining in the deep layer of the ectoderm). Expression of IA1 can be seen in cells within the deep layer (arrowheads) of the ectoderm as well as in cells adhering to the underside of the deep layer (arrow). S: Transversal section of a tail bud stage embryo showing IA1 expression in the dorsal pancreas. T: Embryo in P bisected at the level of the hindbrain showing IA1 staining in the pancreas and in the adrenal medulla. U,Y: Transverse sections through the hindbrain region. Note that IA1 is transiently expressed in differentiating neurons of the neural tube and that IA1 transcripts, like that of Delta1, are located immediately adjacent to the Ngnr1-positive cells. ElrC and CRMP4 are found more peripherally. Tg, trigeminal ganglia; an, anterior neural plate; am, adrenal medulla; dl, deep layer of the ectoderm; dp, dorsal pancreas; fm, forebrain and midbrain neurons; sl, superficial layer of the ectoderm; ov, otic vesicle.
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