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isl1xenopus anterior neural fold 

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Experiment details for isl1

Brade T et al. (2007) Assay

The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development.

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Gene Clone Species Stages Anatomy
isl1.S laevis NF stage 14 anterior neural fold

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  Fig. 2. Spatial expression pattern of Xisl-1. (A) Xisl-1 is expressed in the anteriormost region of the embryo (shown from an anterior view, dorsal is up) including the cement gland anlage (asterisk) and the cardiac crescent (arrow). (B) During early neurula stages Xisl-1 expression extends dorsally adjacent to the neural folds (cephalic placodal area) (arrows). (C) Xisl-1 mRNA additionally marks the profundal–trigeminal placodal area. (D) A parasagittal section (anterior is to the left, dorsal is up) shows the expression of Xisl-1 in the anterior mesendoderm (arrow). (E) At neural tube stages Xisl-1 transcripts are present in the cardiac crescent (arrow) and are also detected in the stomodeum abutting the cement gland on the dorsal side (arrowhead). Xisl-1 expression is maintained in the cephalic placodes and their associated ganglia at least until st. 36 (E–K and data not shown). (F) Xisl-1 is expressed in the heart region (arrow). Punctate expression is seen in precursor cells of the developing vascular system (arrowheads). (G) Xisl-1 transcripts are abundant in the foregut endoderm and pharyngeal mesoderm and expression in the heart region has become restricted to an anterior domain (arrow); arrowhead points to pineal gland. (H) Co-staining for Xisl-1 (light blue) and Nkx2.5 (dark blue) shows that Xisl-1 is expressed more anteriorly compared to Nkx2.5. (I–K) Expression of Xisl-1 in the developing heart (asterisk) decreases and becomes restricted to a dorsolateral domain. aa: aortic arches; IFT: inflow tract; lpm: lateral plate mesoderm; np: neural plate; pPrV: profundal–trigeminal placodal area; gPr: profundal ganglion; gV: trigeminal ganglion; gVII: ganglia of facial nerve VII.
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