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kcna1xenopus spinal cord 

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Experiment details for kcna1

Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development.

Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development.

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Gene Clone Species Stages Anatomy
kcna1.S laevis NF stage 35 and 36 spinal cord

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  F/g~re 5. Kv2.2 mRNA localizes to the ventral spinal cord and perinuclcar somite regions during development of excitability. These views are obtained from 30 pm sections of whole-mount embryos that were hybridized to a Kv2.2 antisense probe. Sections were counterstained with methyl green, which intensely colors nuclei. Dorsal is UP in all panels. In the sagittal sections, rostra1 1s to the r&zt. A, In a cross-section from a stage 23 embryo, Kv2.2 mRNA is restricted to the ventrolateral portion of the neural tube (open u~.rdws) and region around the somite nuclei (filled arrowhead). B, A sense control stage 23 embryo is observed in cross-section; the color is attributable solely to methyl green countcrstaining. Sense controls for other stages and planes of section provide similar results. C, At stage 26, the signal in the ventral portion of the neural tube (open arrowheads) resembles the pattern observed at stage 23 (A). In the somitcs, the signal predominates around nuclei @Ned arrowheads). D, In a parasagittal section of a stage 26 embryo, the Kv2.2 hybridization signal concentrates around the somite nuclei. E, In a sagittal section of a stage 26 embryo, the Kv2.2 hybridization signal concentrates in the ventral region of the neural tube in discrete patches. The Kv2.2 signal delimits the ventral extent of the neural tube, whereas the nf is positioned within the dorsal region. F, G, Sections obtained from stage 35 embryos probed with either anti,cnse Kv2.2 (F) or Kvl.1 (G) probes. The black varicosities surrounding the spinal cord (durk thzn avowheuds) are attributable to pigmented cells found in the embryos used for this experiment, which were caused by the mating of an albino female and a pigmented malt. By stage 35, pigment begins to appear in albino/pigmented embryos. F, By stage 35, Kv2.2 expression in the neural tube (open arrowheud,) appears fainter than at stage 23 (C), which is consistent with what is observed at the whole-mount level (Fig. 4F). G, Kvl.1 mRNA localizes to the dorsal region of the spinal cord indicated by the open arowa. Scale bar (shown in A): A, 50 pm; R, 75 km; C, 100 km; D, 100 Km; E, 200 km; F, 100 pm; G, 100 pm. Abbreviations: nt, neural tube (spinal cord); 5, somites; /zot, notochord.
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