| Search Criteria |
| Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
|---|---|---|---|---|
| lhx1 | xenopus |
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Experiment details for lhx1
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
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| Figure 3. Tiki1 Is Required for Anterior Development(A) Tiki1MO (5, 10, 20, and 40 ng) inhibited protein expression from Tiki1-FLAG but not HA∗Tiki1 mRNAs (500 pg).(B) Tiki1MO (20 ng) caused anterior defects, which were rescued by HA∗Tiki1 mRNA (50 pg). Lateral (left) and dorso-anterior (right) views are shown at stage 42.(C) Statistical data of the Tiki1MO phenotype.(D) Tiki1MO suppressed head organizer gene expression at stages 10.5–11. See also Figure S3 and Tables S1, S2, and S3. |