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lmod2xenopus heart 

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Experiment details for lmod2

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.

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Gene Clone Species Stages Anatomy
lmod2.L laevis NF stage 29 and 30 heart

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  Fig. 1. Structure and developmental expression of the leiomodin (Lmod) and tropomodulin (Tmod) gene families. (A) leiomodin (Lmod1–3) and tropomodulin (Tmod1–4) proteins are structurally related, yet possess unique domains. Lmods and Tmods share actin-binding (A1, A2), tropomyosin-binding (TM1) and leucine-rich-repeat (LRR) domains. A second tropomyosin-binding domain (TM2) is unique to the Tmods. Lmod proteins have a Cterminal extension that contains a third actin binding/WH2 domain (WH2/A3). (B–I) Lmod (C–E) and Tmod (F–I) family gene expression was analyzed during Xenopus embryonic development using in situ hybridization. All embryos are positioned with heads to the left. Expression patterns are shown at the early tailbud stage (st30), during the early stages of myofibrillogenesis. Earlier expression during the neurula stage (st15) is presented in supplementary material Fig. S1. Expression of the definitive striated muscle marker cardiac actin, actna1 (B), was used to indicate cardiac and skeletal muscle tissue in the embryo. Arrows indicate developing skeletal muscle and heart tissues. Only lmod3 (E) and tmod4 (I) are expressed at high levels in developing skeletal muscle.

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Gene Clone Species Stages Anatomy
lmod2.L laevis NF stage 33 and 34 heart

  lmod2 (leiomodin 2 (cardiac)) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 34, lateral view, anterior left, dorsal up.
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