Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Search Criteria
Gene/CloneSpeciesStageAnatomy ItemExperimenter
nodal6xenopus dorsal 

Too many results?Too few results?

Experiment details for nodal6

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.

Good quality Poor quality
Gene Clone Species Stages Anatomy
nodal6.L laevis NF stage 9 dorsal

Display additional annotations [+]
  Fig. 8. Expression of Nieuwkoop, BCNE or Spemann organizer genes is not restored inβ -Catenin/Bmp4/Bmp7-depleted embryos. (A-D) Expression of Xnr6 in the vegetal dorsal side at blastula stage 9 in the Nieuwkoop center requires β-Catenin, is unaffected by knockdown of Bmp4/Bmp7, and is not re-expressed in β-Catenin/Bmp4/Bmp7 triple knockdowns. (E-L) Expression of the BCNE center genes Pintallavis/Hnf3β and Chordin at blastula stage 9 requires β-Catenin, is not affected by the depletion of Bmp4/Bmp7 and fails to be rescued in β-Catenin/Bmp4/Bmp7 triple knockdowns. (M-P) Chordin expression in the Spemann organizer at gastrula stage 10 is eliminated by β-Catenin depletion but is unchanged in Bmp4/Bmp7-depleted embryos. Note that embryos shown in panels D,H,L and P do not express any of the dorsal genes tested, yet still give rise to hyperdorsalized embryos with large head structures. (Q) RT-PCR analysis at stage 9. Dorsal markers are not expressed in embryos lacking β-Catenin orβ -Catenin/Bmp4/Bmp7. (R-V) A simplified model highlighting the interactions taking place at blastula stage between BMP signals and the dorsal BCNE and Nieuwkoop centers.