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osr1xenopus   

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Experiment details for osr1

Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specif...

Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.

Gene Clone Species Stages Anatomy
osr1 tropicalis NF stage 15 endoderm , central endoderm
osr1 tropicalis NF stage 28 stomodeal-hypophyseal primordium , intermediate mesoderm , endoderm , hindgut , alimentary system , [+]
osr1 tropicalis NF stage 33 and 34 otic vesicle , brain , midbrain , hindbrain , spinal cord , [+]
osr1 tropicalis NF stage 42 lung , alimentary system , esophagus , stomach , foregut

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  Fig. 1. osr1 and osr2 are dynamically expressed in the developing Xenopus foregut and are required for lung development. (A-G′′) In situ hybridization of osr1 (A-D) and osr2 (E-H) expression in Xenopus tropicalis embryos and isolated gut tubes (D,H) at the indicated stages (st), anterior leftwards, dorsal upwards. Stage 15 embryos (A,E) are bisected and stage 33 embryos (C′-C[H11630],G′-G[H11630]) are sectioned to show the endoderm (outlined in yellow in A,E). fg, foregut; hg, hindgut; de, dorsal endoderm; pe, posterior endoderm; e, esophagus; l/t, presumptive lung and trachea; lv, liver; lpm, lateral plate mesoderm; k, kidney; s, stomach. (I-N′) surfactant protein c (sftpc) (I-L) and nkx2.1 (M,N′) expression in embryos injected on one side with Osr1/Osr2-MOs (10 ng each) or negative control mutated oligos MM-MO (20 ng) shows lung agenesis on the Osr1/Osr2-depleted side. (M’-N′) Sections. Numbers of embryos with the shown phenotype are indicated. Dorsal view of an isolated gut tube (K,L) shows the lung bud absent on the injected side (red arrow).