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Gene/CloneSpeciesStageAnatomy ItemExperimenter
otx2xenopus dorso-lateral marginal zone 

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Experiment details for otx2

Kurata T and Ueno N (2003) Assay

Xenopus Nbx, a novel NK-1 related gene essential for neural crest formation.

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Gene Clone Species Stages Anatomy
otx2.S laevis NF stage 11 dorso-lateral marginal zone

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  Fig. 4. Nbx acts as a transcriptional suppressor. (A) Schematic representation of Nbx, VP-Nbx, and EnR-Nbx constructs. (B) Phenotypes of Nbx (200 pg)-injected embryos. The Nbx injection into the dorsal side caused a head defect. (C) Uninjected embryos developed normally. (D, E) Wholemount in situ hybridization analysis of Nbx (200 pg)- and -gal (100 pg)-injected embryos at stage 11. Nbx suppressed the organizer markers Otx2 (D) and goosecoid (E). (F, G) Whole-mount in situ hybridization analysis of -gal (100 pg)-injected embryos. -gal injection did not affect the expression of Otx2 (F), goosecoid (G). (H) Phenotype of VP-Nbx (100 pg)-injected embryo. The VP-Nbx injection into the ventral side caused ectopic cement gland formation (arrowhead in H). (I:) Uninjected embryos developed normally. (J�M) Whole-mount in situ hybridization analysis of VP-Nbx (100 pg)- and -gal (100 pg)-injected embryos. VP-Nbx injection into the dorsal side led to the expanded expression of Otx2 (J) and goosecoid (K). VP-Nbx injection into the ventral side resulted in the ectopic expression of Otx2 (L) and goosecoid (M) at the injected region. (N) Phenotype of EnR-Nbx (100 pg)-injected embryo. The injection caused a head defect. (O:) Uninjected embryos developed normally.
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