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Fig. 8.
Fzd3 and Pax2 are upstream ofalcam. A. After injection of Pax2 MO, alcam expression was reduced on the injected side of the embryo at stage 21 (black arrow). A quantitative representation is given. B. After injection of Fzd3 MO, pax2 expression was mildly, but significantly reduced on the injected side of the embryo at stage 21 (black arrow). C. Schematic drawing. Fzd3 regulates alcam expression via the β-catenin independent Wnt/JNK pathway and Pax2. Abbreviations: n, number of independent experiment; N, total number of analyzed embryos. Error bars indicate standard error of the mean (s.e.m.); ** p≤0.01. p values were calculated by a non-parametric Mann–Whitney rank sum test.
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