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pax2xenopus choroid fissure 

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Experiment details for pax2

Qiu R et al. (2009) Assay

The role of miR-124a in early development of the Xenopus eye.

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Gene Clone Species Stages Anatomy
pax2.L laevis NF stage 33 and 34 choroid fissure

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  Fig. 3. Effects of miR-124a overexpression on eye development in Xenopus. miR-124a or control (miR-198) miRNA precursors (0.025 pmol) were microinjected into one Xenopus dorsal-animal blastomere at the 8-cell stage. (A) The head region of the injected Xenopus embryo grown to stage 46 is shown from the dorsal or lateral view. The pink arrow marks an enlarged and pigmented optic stalk-like structure induced by miR-124a injection. (B) The structure of wild-type and abnormal eyes of a stage 46 embryo injected by miR-124a is shown on a series of transverse sections (5 μm) from anterior to posterior. The sections were stained with hematoxylin (blue)–eosin solution (pink). Pink arrows indicate the optic nerve. The red arrowhead shows the reduced retina ganglion layers. (C) The expression (dark blue) of Pax2, Rx1, and Pax6 after miR-124a overexpression was detected by whole mount in situ hybridization at stages 13, 20, and 33. Stage 13 and 20 embryos are shown from the anterior view, and the eyes of stage 33 embryos are shown from the lateral view. Scale bars: 300 μm (A and C); 100 μm (B).
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