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Fig. 4. Runx1 expression in RB sensory neurons depends on Pax3 and Zic1. (A) Comparative expression of Pax3, Zic1 and Runx1 in stage-matched embryos indicates that the Runx1 expression domain overlaps with that of these two NPB specifiers. (B) Embryos injected with Pax3MO (50 ng) or Zic1MO (45 ng) in one blastomere at the 2-cell stage exhibit a strong reduction of Runx1 as well as N-Tub and Ngnr1 expression in RB progenitors. The injected side is on the right. In all panels embryos are viewed from the dorsal side, anterior to top. |
