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Fig. 1. The pattern of expression of the XIF3 gene during the neurula stages. (A) At stage 15, XIF3 transcripts are found in a line either side of the midline and probably correspond to the future primary motor neurons Bilateral patches adjacent to the anterior neural plate represent expression in the placodal component of the trigeminal ganglia (arrowheads). (B) By stage 15+, XIF3 expression is also detectable in a stripe either side of the midline corresponding to the primary interneurons (arrowhead). (C) By stage 16, punctate XIF3 staining is apparent in the primary sensory neuron (Rohan-Beard cell) stripe (arrowhead). In addition there is diffuse XIF3 staining in neuroectoderm between the motor neuron and interneuron stripes and to the same anterior limit as these stripes. (D) At stage 17 there IS additional diffuse bilateral staining in the prospective midbrain (arrow), though this expression is transient. IE) By stage 18, punctate staining is seen in two patches adjacent to the anterior boundary of the neuroectoderm corresponding to neurons in the nasal placodes (arrowed). (F) At stage 20, the neural tube is almost completely folded and the primary neurons are strongly stained. Expression in the trigeminal ganglia extends around the eye. |
