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Fig. 1. Coordinated spatial and temporal expression of histone deacetylase Rpd3 and corepressor Sin3. Digoxigenin labeled Rpd3 and Sin3 antisense mRNA was used as probes in whole mount analysis of their developmental expression in albino Xenopus embryos. (A,B,C,D) Rpd3 and (E,F,G,H) Sin3 expression was examined at the end of neuralation (stage 18/21, A,E), tailbud (stage 31/32,B,F), hatching stages (stage 35/36, C,G), and at the onset of feeding (stage 45, D,H). Both Rpd3 and Sin3 were abundantly ex- pressed, particularly in dorsal axial structures and in head and anterior structures. Their expression diminished by tadpole feeding. Their expression profiles overlap extensively. Note that Rpd3 was also expressed in the dorsal region of the embryo in the area of the proctodeal channel (boxed area, which was enlarged in the insert in B), where stromelysin-{remaining fig caption text missing from publication} |
