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six1xenopus   

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Experiment details for six1

van Grunsven LA et al. (2007) Assay

XSip1 neuralizing activity involves the co-repressor CtBP and occurs through BMP dependent and independent mechanisms.

Gene Clone Species Stages Anatomy
six1.L laevis NF stage 13 to NF stage 21 ectoderm , preplacodal ectoderm , anterior placodal area , neurogenic placode

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  Suplemental Figure2: Overexpression of XSip1 or XSip1δCtBP does not turn on neural crest or placodal markers. Slug expression marks neural crest progenitors. Six1 expression marks cephalic neurogenic placodes. (A) Embryos injected animally with the indicated ARN together with LacZ RNA. Noth that while overexpression of both XSip1 or XSip1δCtBP leads to suppression of epidermis, Slug and Six1 expression are not induced. (B) Animal caps explanted at stage 9 derived from embryos overexpressing XSip1δCtBP or control uninjected embryos. Note that while overexpression of XSip1δCtBP inhibits epidermal keratin expression, Slug and Six1 expression are not induced.