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six1xenopus anterior branchial crest 

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Experiment details for six1

Adams DS et al. (2016) Assay

Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome.

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Gene Clone Species Stages Anatomy
six1.L laevis NF stage 28 anterior branchial crest

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  Fig. S3. WISH for craniofacial patterning genes in embryos injected with the dominant negative (DN) D71V mRNA and with WT KCNJ2. Ten markers were used to characterize the effect of the DN and WT KCNJ2s on craniofacial patterning. The marker is indicated to the left of each row; two columns of images each are presented for untreated controls (No Treatment), embryos injected with the D71V DN variant, and embryos injected with the WT KCNJ2 construct. The normal pattern, at two different stages, is shown in the two left most columns. Examples of mispatterning of the markers are shown in the other columns. There was no consistent difference between the effects of the DN and the WT, indicating that the direction of change of Vmem does not prescribe a particular subset of defects.
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