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Gene/CloneSpeciesStageAnatomy ItemExperimenter
sox11xenopus head mesenchyme 

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Experiment details for sox11

Cizelsky W et al. (2013) Assay

sox4 and sox11 function during Xenopus laevis eye development.

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Gene Clone Species Stages Anatomy
sox11.L laevis NF stage 33 and 34 head mesenchyme
sox11.L laevis NF stage 41 head mesenchyme

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  Figure 1. Spatial expression of sox4 and sox11 during Xenopus laevis embryogenesis. A–N sox4 expression, A’–N’ sox11 expression. The cement gland is depicted by a dotted circle. A,A’: At stage 1, sox4 and sox11 are maternally expressed at the animal pole (arrows). B,B’: During gastrulation, sox4 and sox11 are expressed in the expanding mesoderm surrounding the blastoporus (arrows). Dotter lines indicate the level of sections shown in C,C’. C,C’: Sections through embryos at stage 10.5 indicate a strong expression in the mesoderm (m). Ectoderm (ec) and endoderm (en) are negative for sox4 and sox11. bc = blastocoel. D,D’: At stage 15, sox4 and sox11 are strongly expressed in the anterior neural tissue (white arrowheads). In addition, sox4 transcripts are visualized in the cardiac progenitors (red arrowhead) whereas sox11 is detected at the placodal primordium (white arrow). E,E’: At stage 20, sox4 and sox11 are expressed in the neural tube (black arrows), the forebrain (green arrowheads), the eye anlagen (white arrowheads), the migrating neural crest cells (white arrows) and cardiac progenitor cells (red arrowheads). F,F’: Sox4 and sox11 mRNA molecules are detected in the neural tube (black arrows), the eye (white arrowheads) and the migrating neural crest cells (white arrows). The dotted line indicates the level of section shown in K and K’. G,G’: At stage 27, sox4 and sox11 are expressed in the hindbrain (black arrows), the eye (white arrowheads), the forebrain (green arrowheads), and the cardiac region (red arrowheads). H,H’: Sox4 and sox11 are strongly expressed in the hindbrain (black arrows) and branchial arches (white arrows). The dotted line indicates the level of section shown in L and L’. I,I’: Sox4 and sox11 transcripts are visualized in the hind- and forebrain (black and green arrows) as well as branchial arches (white arrows). Sox4 is additionally visualized in the vitelline veins (red arrow). Dotted line indicates the level of section shown in M and M’. J,J’: At stage 41, sox4 and sox11 are expressed in the head mesenchyme (white arrows), the forebrain (green arrowheads) and migratory primordium of the lateral line system (m). K–N,K’–N’: Transverse sections at indicated stages. K,K’: Sox4 and sox11 are detected in the optic vesicle (white arrowheads). Note that expression is missing from the optic stalk (os). L: Sox4 transcripts are detected in the retina (yellow arrow), the cornea epithelium (Ce) and the hindbrain (black arrow). In addition, sox4 is expressed in the placodes and the ganglia of the profundal (pPr; gPr) and trigeminus (pV; gV) nerve as well. Note that the placodal expression is only in the deep layers whereas the superficial layer is quite free of staining. L’: Sox11 expression is detected in the brain (black arrow), strongly in the ganglion cell layer of the retina (white arrowhead) with a gradient towards outer retinal layers. M: Sox4 transcripts are visualized in the retina (yellow arrow), the corneal epithelium (Ce), the mid- (black arrow) and forebrain (green arrowhead). A strong expression in the profundal (gPr) and trigeminus (gV) ganglia is shown. M’: Sox11 mRNA is visualized in the differentiated dorsal interneurons of the neural tube (black arrow) and the retina with a strong expression in the ganglion cell layer (white arrowhead). N, N’: Sox4 and sox11 are expressed in the ciliary marginal zone (CMZ) of the eye