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sox5xenopus   

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Experiment details for sox5

The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6.

The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6.

Gene Clone Species Stages Anatomy
sox5.S laevis NF stage 15 neural crest , paraxial mesoderm , cranial neural crest
sox5.S laevis NF stage 23 neural crest , presomitic mesoderm , somite , eye , cranial neural crest , [+]
sox5.S laevis NF stage 29 and 30 otic vesicle , mandibular crest , hyoid crest , neural crest , presomitic mesoderm , [+]
sox5.S laevis NF stage 35 and 36 otic vesicle , head region , presomitic mesoderm , somite , branchial arch , [+]

  Fig. S6. Characterization of Xenopus laevis Sox5 and Sox6. (A) Amino acid sequence alignment of Sox5 or Sox6 proteins from human (Homo sapiens) (Sox5, NP_008871; Sox6, NP_001139291), mouse (Mus musculus) (Sox5, NP_035574; Sox6, NP_035575), chicken (Gallus gallus) (Sox5, CAF25288; Sox6, XP_421000), frog (Xenopus laevis) (Sox5, AB682776; Sox6, AB682777) and zebrafish (Danio rerio) (Sox5, AAI63449; Sox6, NP_001116481). Identical and highly conserved amino acids are highlighted in black and gray boxes, respectively. Dashed lines indicate gaps. Two potential coiled-coil domains and the HMG box are underlined in blue and magenta, respectively. (B) The temporal expression patterns of xSox5 and xSox6 during embryonic development were analyzed by qRT-PCR. (C) Whole-mount in situ hybridization for xSox5 was performed on embryos at stages 15, 23, 29/30 and 35/36. NC, neural crest; PM, paraxial mesoderm; PSM, presomitic mesoderm; BA, branchial arch; VBWM, ventral body wall muscle. (D) Anterior and dorsal view of embryos shown in C. NC, neural crest; NF, neural fold; PM, paraxial mesoderm; OV, otic vesicle; BA, branchial arch; FB, forebrain; MB, midbrain; HB, hindbrain.