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Fig. 7. 5-HT2B loss of function results in the downregulation of Xbap expression in postmigratory NCCs. The injected side, visualized by n-β-gal staining (red), is always on the right. (A,A′,B,B′,C,C′) Lateral view of stage 37 Xenopus embryos hybridized with Xbap (A,A′), XHoxa2 (B,B′) and XHand2 (C,C′) probes. (A′) Frontal view of the embryo in A. (A′′′,B′,C′) Vibratome coronal sections across the line in A, B and C, respectively. (A-A′′′) The Xbap expression is reduced on the injected side of stage 37 5-HT2B morphants (arrows in A′, A′′′) as compared with the control side. XHoxa2 (B-B′) and XHand2 (C-C′) expression is unaffected. (D,D′) Lateral view of a whole-mount stage 28 5-HT2B morphant hybridized with XSox9 probe. |
