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spry1xenopus hindlimb digit 2 

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Experiment details for spry1

Wang YH and Beck CW (2014) Assay

Distal expression of sprouty (spry) genes during Xenopus laevis limb development and regeneration.

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Gene Clone Species Stages Anatomy
spry1.L laevis NF stage 55 hindlimb digit 2

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  Fig. 2. In situ hybridisation of spry1a, spry2, spry4 and fgf8b in Xenopus laevis developing hindlimbs from stage 49 to 55. Fgf8b is included to show the location of the AER at developmental stages 50–54. Specific staining is dark purple. Black spots in some panels are melanophores in pigmented specimens. Black arrows indicate distal expression, red arrows localised expression in more proximal mesenchyme of older limbs, and thin white arrows indicate possible forming blood vessels. Roman numerals show detectable staining in some digits. The AER is indicated in some panels to show absence of spry1a and spry4 and presence of spry2 and fgf8b transcripts. All limbs are oriented proximal to the left and posterior uppermost, with the tadpole on its right side, except for panels B, I and V where both hind limbs are viewed from the anterior with the tadpole placed on its back. For stage 54 and 55 limbs only the autopod is shown for spry1a, spry4 and fgf8b, as by this stage there is no proximal staining. Developmental stage is in the bottom right of each panel and limbs are photographed to the same scale, except for panel T which shows histological section through a stage 53 limb bud to show expression of spry2 in the AER around digit IV. Scale bar in T is 50 um.

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Gene Clone Species Stages Anatomy
spry1.L laevis NF stage 55 hindlimb digit 2

  spry1 (sprouty homolog 1, antagonist of FGF signaling ) gene expression in Xenopus laevis embryonic hindlimb, assayed via in situ hybridization, NF stage 55, proximal to the left and posterior uppermost, with the tadpole on right side.
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