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Gene/CloneSpeciesStageAnatomy ItemExperimenter
tbx5xenopus   

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Experiment details for tbx5

Peterkin T et al. (2007) Assay

Redundancy and evolution of GATA factor requirements in development of the myocardium.

Gene Clone Species Stages Anatomy
tbx5.S laevis NF stage 28 retina , cardiac mesoderm , dorsal , lateral plate mesoderm , heart primordium

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  Fig. 1. Cardia bifida is evident in GATA4, 5 and 6 morphants, but cardiac gene expression is only affected in GATA6 depleted Xenopus embryos. (A) Cardiac tissue stained for MLC fails to migrate to the midline in embryos injected singly with GATA4, 5 or 6 morpholinos. (B, C) Expression levels of MLC, Nkx2.5, Tbx5 and CA remain unchanged in GATA4 and 5 morphants compared with control uninjected embryos at stage 28. (D) Expression levels of MLC, Nkx2.5, Tbx5 and CA are substantially decreased in GATA6 morphants at stage 28.