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Fig. 4. E-cadherin mediated CNC migration cannot be rescued by other classical cadherins. (A) Embryos were injected with E-cadMO together with XB-cadherin, Cadherin-11 or N-cadherin mRNA, respectively. In situ hybridization using AP2 was performed at stage 25 to analyse CNC migration in vivo. (B) Statistic of the in situ hybridization. N=number of experiments and n=number of embryos. * Indicates injected site and bars show average percentage of embryos with CNC migration defect. At least three independent experiments were performed and the average percentage is shown with standard deviations. Significance is calculated according to fisher’s exact test. Scale bar: 200 μm. |
