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Fig. 1. Sequence alignment and expression pattern of XTcf-4. (A) Alignment of XTcf-4 with its human and murine homologs. The C-terminus reveals homology to the variants Tcf-4B and Tcf-4E. Note: the 19 aa insertion in XTcf-4 at position 126. (B) RT-PCR analysis reveals that the expression of XTcf-4 starts from late neurula stages onward. (C) Whole-mount in situ hybridizations show that XTcf-4 expression is restricted to the anterior part of the midbrain, stage 22 lateral view, stage 30 dorsal view. |