|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
ret
|
|
laevis
|
NF stage 15
to
NF stage 20
|
|
ret
|
|
laevis
|
NF stage 26
to
NF stage 32
|
intermediate mesoderm
,
trigeminal ganglion
,
pharyngeal region
|
smad4
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
,
neuroectoderm
,
neural plate
|
smad4
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
brain
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
hras
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
|
hras
|
|
laevis
|
NF stage 26
to
NF stage 32
|
head
,
periotic region
|
ptgs2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
epidermis
,
neural groove
|
ptgs2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
dorsal fin
,
ventral tail fin
|
jak2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
|
jak2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
notochord
|
zeb1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
chordal neural plate
,
neural plate
|
zeb1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
forebrain
,
midbrain
,
hindbrain
,
midbrain-hindbrain boundary
,
[+]
|
pkm
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
|
pkm
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
midbrain
,
somite
,
eye
|
axl
|
|
laevis
|
NF stage 15
to
NF stage 20
|
epidermis
|
axl
|
|
laevis
|
NF stage 26
to
NF stage 32
|
spinal cord
,
proctodeum
,
head
|
prkaa1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
|
prkaa1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
brain
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
ahr
|
|
laevis
|
NF stage 15
to
NF stage 20
|
|
ahr
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
eye
,
pharyngeal region
|
pik3ca
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
|
pik3ca
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
forebrain
,
midbrain
,
somite
,
eye
,
[+]
|
hgf
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural plate border
|
hgf
|
|
laevis
|
NF stage 26
to
NF stage 32
|
head
,
neurogenic placode
|
mcam
|
|
laevis
|
NF stage 15
to
NF stage 20
|
|
mcam
|
|
laevis
|
NF stage 26
to
NF stage 32
|
midbrain
,
presomitic mesoderm
,
trigeminal ganglion
,
intersomitic region
|
slc16a1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
,
neuroectoderm
,
neural plate
|
slc16a1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
presomitic mesoderm
,
eye
,
head
,
pharyngeal region
|
smad1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
,
neuroectoderm
,
neural plate
|
smad1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
forebrain
,
midbrain
,
hindbrain
,
spinal cord
,
[+]
|
pim1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
paraxial mesoderm
,
neural plate border
|
pim1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
forebrain
,
midbrain
,
hindbrain
,
spinal cord
,
[+]
|
nras
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
|
nras
|
|
laevis
|
NF stage 26
to
NF stage 32
|
notochord
|
tert
|
|
laevis
|
NF stage 15
to
NF stage 20
|
|
tert
|
|
laevis
|
NF stage 26
to
NF stage 32
|
|
|
|
FIGURE S5. Genes involved in cancer show different patterns of expression. A, spatial expression of genes that promote or are upregulated during cancer development/progression. B, spatial expression of genes that can play dual roles (promote or are upregulated in some cancer types while repress or are downregulated in some other types) during the development/progression of different cancer types. Each embryo is oriented with the anterior to the left. Dorsal view is shown for neurula embryos, and lateral view is shown for tailbud, with dorsal side to the top of each panel. Typical expression domains are labeled but the same expression domain in different panels may not be labeled repeatedly. A, anterior; ad, adenohypophysial placode; anp, anterior neural plate; anpb, anterior neural plate border; ba, branchial arch; cg, cement gland; cgp, cement gland primordium; cnh, chordoneural hinge; cnp, chordal neural plate; d, dorsal view; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; l, lateral view; mb, midbrain; ng, neural groove; np, neural plate; npb, neural plate border; P, posterior; pd, pronephric duct; pm, paraxial mesoderm; ps, posterior somite; sc, spinal cord; sm, somite; tg, trigeminal nerve. |