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wnt4xenopus olfactory region 

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Experiment details for wnt4

Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros.

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Gene Clone Species Stages Anatomy
wnt4.L laevis NF stage 28 olfactory region

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  Fig. 9. rfng promotes expression of wnt4 and components of the Notch pathway. (A-C) X. laevis embryos were injected as previously described and cultured to stage 28, with beta-galactosidase mRNA co-injected to act as a lineage tracer (red staining on injected side). Ectopic wnt4 (A), delta1 (B) and serrate1 (C) expression was detected after rfng mRNA injection. Asterisk denotes injected side. (D) A model for early stage proximal pronephrogenesis regulated by the Notch signalling pathway. We propose a pool of cells undergoing Notch signalling and located on the lateral side of the dorso-anterior pronephros anlagen at tail bud stages of development, mediate medio-lateral patterning, permitting the glomus and tubules to develop independently. Blue arrows indicate proposed genetic hierarchy; red arrows indicate directional secretion of Wnt4. See text for full description.
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