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aplnxenopus hypochord 

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Experiment details for apln

Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal va...

Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo.

Gene Clone Species Stages Anatomy
apln.L laevis NF stage 33 and 34 hypochord

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  Fig. 2. In situ hybridization analysis of APJ and apelin expression during Xenopus development. (A) In the Xenopus embryo at the early tailbud stage (stage 32) APJ expression marks developing blood vessels throughout the embryo. The aortic arch region (aa) and the posterior cardinal vein (pcv), ventral vascular plexus (plex) and branching intersegmental vessels (isv) are indicated. The region of expression in the tailbud does not appear to be associated with vascular tissue. (B) At stage 32, apelin expression is detected in the anterior region of the posterior cardinal vein, the extending intersegmental vessels and the developing blood vessels surrounding the eye. Apelin expression is also detected in the ventral neural tube (nt). (C) At stage 35, APJ transcripts are detected throughout the developing vasculature, including the assembling vascular plexus in ventrolateral regions of the embryo and distinctly in the intersegmental vessels. (D) At stage 35, apelin expression is visible in the branching intersegmental vessels but expression in the vessels surrounding the eye is now absent. No apelin transcripts are detected in the plexus region. (E) Transverse section through anterior trunk region of stage 32 embryo stained for apelin transcripts. Note prominent expression in the posterior cardinal veins. (F) Transverse section through trunk of stage 34 embryo stained for apelin. In addition to posterior cardinal veins, expression is visible in the hypochord (hc) and in paired regions within the ventral neural tube (nt). (G) Longitudinal section through ventral neural tube of stage 34 embryo stained for apelin. Anterior is to the left. Note that expression is not continuous but appears to mark paired motor neurons (Saha et al., 1997) (H).