| Search Criteria |
| Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
|---|---|---|---|---|
| bmp4 | xenopus | retinal layer [+] |
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Experiment details for bmp4
Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye.Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye.
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| Figure 5. Inhibition of Fgfrs during the eye field stage results in expansion of dorsal markers in the nasal retina. A–C: Representative images of tbx3 expression in the eyes of Stage 32 embryos exposed to control or SU5402 solutions for 5 hr at Stage 12 (A, B), or Stage 24 (C). The ventral boundary of expression domains is indicated (arrowheads). D: The distance from the ventral retina to the ventral boundary of the tbx3 or bmp4 expression domains in the nasal (X-N) and temporal (X-T) retina was measured in control- and Fgfr inhibitor-treated embryos. E, F: The tbx3 expression domain is expanded in the nasal retina (therefore the distance to the base of the domain is diminished) and unchanged in the temporal retina after SU5402 treatment at Stage 12 (E; N=4 experiments with a minimum 8 embryos/group), and unchanged in both the nasal and temporal retina after treatment at Stage 24 (F; N=3 experiments with a minimum of 8 embryos/group). G, H: Lateral view of the eyes of Stage 32 embryos treated with a control or SU5402 solution at Stage 12. I: The bmp4 domain is expanded in the nasal retina and unchanged in the temporal retina (bmp4, N=2 experiments with a minimum of 7 embryos/group). Values in graphs are mean distance ± SEM; means were compared using unpaired t-tests. *P < 0.05, **P < 0.01). Grey dashed line in A, B, C, G, H indicates the outline of the developing neural retina, and the black dashed line divides the retina into nasal and temporal halves.Download figure to PowerPoint |