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Fig. 1. p27Xic1 is expressed in cells destined to become primary neurones. Whole-mount in situ hybridisation at indicated stages show expression of p27Xic1 (A-C,G,I) or XMyT-1 (D-F,H). Except for G, figures show a dorsal view with anterior towards the bottom. Both p27Xic1 and XMyT-1 are found in lateral, intermediate and medial stripes of primary neurones, placodes (arrows) and the trigeminal ganglia (arrowheads). (G) Stage 13 embryos show p27Xic1 staining in the epidermis. (H) Double in situ hybridisation demonstrates overlap between p27Xic1 (purple) and XMyT-1 (light blue). (I) Vibratome section of a stage 15 embryo shows p27Xic1 expression in the myotome (My), notochord (Not) and primary neurone precursors (PNP) in the sensorial layer of the neural plate (arrow). |
