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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
pnhd
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
pnhd
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
neural crest
,
neural plate border
|
pnhd
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural crest
,
neural plate border
|
hoxa1
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
hoxa1
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
chordal neural plate
|
hoxa1
|
|
laevis
|
NF stage 13
to
NF stage 21
|
epidermis
,
neural plate
|
pax3
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ectoderm
|
pax3
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
ectoderm
|
pax3
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural plate border
|
cdx2
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
marginal zone
|
cdx2
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
circumblastoporal collar
|
cdx2
|
|
laevis
|
NF stage 13
to
NF stage 21
|
chordal neural plate
|
axin2l
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
axin2l
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
neural plate border
|
axin2l
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural plate border
|
wnt8a
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
wnt8a
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
paraxial mesoderm
|
wnt8a
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural plate border
|
gbx2.2
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
dorso-lateral marginal zone
|
gbx2.2
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
ectoderm
|
gbx2.2
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural plate
,
neural plate border
|
ngfr
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
marginal zone
|
ngfr
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
ectoderm
,
chordal neural plate
|
ngfr
|
|
laevis
|
NF stage 13
to
NF stage 21
|
ectoderm
,
chordal neural plate
|
tacc1
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
|
tacc1
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
ectoderm
,
circumblastoporal collar
|
tacc1
|
|
laevis
|
NF stage 13
to
NF stage 21
|
neural plate
|
hes6.1
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
hes6.1
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
circumblastoporal collar
|
hes6.1
|
|
laevis
|
NF stage 13
to
NF stage 21
|
mesoderm
|
znf703
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
znf703
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
ectoderm
,
neural plate
|
znf703
|
|
laevis
|
NF stage 13
to
NF stage 21
|
ectoderm
,
neural plate
|
esr-5
|
|
laevis
|
NF stage 11.5
to
NF stage 12
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
esr-5
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
presomitic mesoderm
|
esr-5
|
|
laevis
|
NF stage 13
to
NF stage 21
|
presomitic mesoderm
|
hes5.9
|
|
laevis
|
NF stage 12.5
to
NF stage 13
|
mesoderm
,
circumblastoporal collar
|
hes5.9
|
|
laevis
|
NF stage 13
to
NF stage 21
|
mesoderm
|
|
|
Fig. 4. In situ hybridization shows that the expression patterns of many characterized and candidate Wnt/β-catenin direct target genes resemble wnt8 expression. Genes are grouped based on functional role. (A) Expression of wnt8 at different developmental stages. (B) Expression of a few characterized direct target genes of Wnt/β-catenin at different developmental stages. (C) Expression of selected candidate direct target genes. Stages 11.5-12 and 12.5-13 are blastopore view with dorsal up. Neurula stage is dorsal view with anterior up. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
pnhd
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
hoxa1
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
axin2l
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
gbx2.2
|
|
laevis
|
NF stage 11.5
|
dorso-lateral marginal zone
|
ngfr
|
|
laevis
|
NF stage 11.5
|
marginal zone
|
hes6.1
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
znf703
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
esr-5
|
|
laevis
|
NF stage 11.5
|
ventral marginal zone
,
ventro-lateral marginal zone
,
dorso-lateral marginal zone
|
|
|
Fig. 5. Expression of Wnt/β-catenin target genes is reduced by dkk-injection. (A, C, E) Normalized counts from RNAseq data comparing uninjected control (UC) and dkk-injected embryos for selected known (A) and candidate (C, E) target genes at stage 11.5 (mid-gastrula). (B, D, F) In situ hybridization showing expression pattern of known (B) and candidate (D, F) target genes. Embryos were injected in the right (asterisk) 2 blastomeres at the 4-cell stage with a total of 100 pg dkk. Blue box indicates that embryo was cleared in either benzyl benzoate:benzoic acid (BB:BA) or benzyl benzoate alone (BB; to reduce transparency and visualize the archenteron). Blastopore view with dorsal up, except pnhd is dorsal view with anterior up. |
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hes5.9 (hairy and enhancer of split 5, gene 9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 11.5-12, blastopore view, dorsal up.
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