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Fig. 1. Xrx1 expression in the proliferative region of the anterior neural plate is controlled by Hedgehog and neurogenin signaling. (A,B) Expression of Xrx1 (light blue) in relation to the expression of (A) X-Delta-1 (purple) and (B) X-ngnr-1 (purple) in stage 13 embryos; frontodorsal views. (C) Sagittal section of a stage 13 embryo showing Xrx1 expression in the deep sensorial layer of the neuroectoderm. (D,E) Stage 14 embryos injected with X-chh (D) and X-shh (E) showing ectopic expression of Xrx1 (blue); frontal views, dorsal towards the top. (F,G) Embryos injected with X-ngnr-1 displaying repression of Xrx1 (blue, F, stage 13) and ectopic expression of N-tubulin (blue, G, stage 16); frontodorsal views. The injected side of the embryos (to the right of vertical bars representing the midline) is indicated (inj). Red staining represents expression of co-injected lacZ lineage tracer. d, deep neuroectodermal layer; s, superficial neuroectodermal layer. |
