|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
hoxb3
|
|
tropicalis
|
NF stage 28
|
presomitic mesoderm
,
rostral presomitic mesoderm
|
sox3
|
|
tropicalis
|
NF stage 28
|
brain
,
forebrain
,
midbrain
,
hindbrain
,
spinal cord
,
[+]
|
pax2
|
|
tropicalis
|
NF stage 14
|
pre-chordal neural plate
,
neural crest
,
cranial neural crest
,
optic field
,
anterior neural ridge
|
pax2
|
|
tropicalis
|
NF stage 28
|
otic vesicle
,
hindbrain
|
dlx5
|
|
tropicalis
|
NF stage 28
|
neural crest
,
branchial arch
,
cranial neural crest
|
ap2a1
|
|
tropicalis
|
NF stage 14
|
neural crest
,
cranial neural crest
|
myod1
|
|
tropicalis
|
NF stage 14
|
mesoderm
,
presomitic mesoderm
,
paraxial mesoderm
|
|
|
S3 Fig. Patterning and Apoptosis in nol11 morphants.
A) Somite, CNC and neural development appear intact in nol11 morphants at stage 14 as assayed by myoD, ap2 and pax2 expression. Expression of xnot appears reduced at stage 28. B) Reduced dlx5 expression and BA hypoplasia on treated side of a stage 28 embryo. Neural patterning is normal at this stage as assayed by expression of pax2, hoxb3 and sox3. C) Whole mount TUNEL staining of treated and untreated sides of a stage 28 embryo. Note the increased staining in the craniofacial regions of the morphant side.
doi:10.1371/journal.pgen.1005018.s003 |