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Gene/CloneSpeciesStageAnatomy ItemExperimenter
olfm1xenopus glossopharyngeal nerve 

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Experiment details for olfm1

Moreno TA and Bronner-Fraser M (2001) Assay

The secreted glycoprotein Noelin-1 promotes neurogenesis in Xenopus.

Gene Clone Species Stages Anatomy
olfm1.S laevis NF stage 35 and 36 glossopharyngeal nerve

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  FIG. 3. Noelin-1 and -2 expression during development. Whole mount in situ hybridization with a probe to the Z exon reveals the distribution of Noelin-1 and Noelin-2 transcripts in the neural tube and cranial ganglia. All embryos are oriented with anterior to the right. A: Earliest expression is seen after neural tube closure in the spinal cord and trigeminal ganglia at stage 22. B: By stage 27 cells in the olfactory placodes and in the trigeminal (V) and geniculate (VII) ganglia are strongly reactive. Punctate staining is visible in the pineal gland and spinal cord. C: A stage 33 embryo shows increasing signal in the Vth and VIIth ganglia, olfactory pits, pineal gland and spinal cord. A population of cells in the retina is also positive for Noelin-1 and -2. D: By stage 35/36 the IXth and Xth ganglia are also positive for the transcripts. A small number of cells in the branchial arches express the Z exon (arrowhead). E-G: Dorsal views of embryos in A-C. E: Stage 22 embryo shows staining in the Vth ganglia and in the spinal cord. Transcripts are not detected in the brain at this stage. The black arrow marks the anterior extent of Noelin-1 and -2 signal in the neural tube. F: By stage 27, spinal cord staining extends into the brain and up to the level of the midbrain. The pineal gland and olfactory placodes are visible. G: At stage 33 the signal is increasingly intense in the cranial ganglia, spinal cord, and more rostrally into the forebrain. e, eye; hb, hindbrain; o, olfactory placode/pit; p, pineal gland; sc, spinal cord; V, trigeminal; VII, geniculate; IX, glossopharyngeal; X, vagal; asterisks mark the general position of otic vesicles. Brown color is due to melanocytes in the skin or retinal pigmented epithelium in the eye.

Gene Clone Species Stages Anatomy
olfm1.S laevis NF stage 35 and 36 glossopharyngeal nerve

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  FIG. 4. Cranial expression of Noelin-1 and -2. 10mmsections through head regions of a stage 35 embryo similar to that in Fig. 3D, stained with a probe to the Z exon. A: A midbrain-region transverse section reveals Noelin-1 and -2-positive cells in the pineal gland and brain. Arrow points to the body of the gland, arrowhead denotes cells that are not positive for Noelin-1 or -2. B: A hindbrain section at the midotic vesicle level shows signal in the VIIIth ganglion (arrow) and faintly in the IXth ganglion (arrowhead) ventral to the otic vesicle. C: Parasagittal section through the eye, Vth and VIIth ganglia and the otic vesicle. The retinal ganglion cell layer also contains signal. D: A higher-power view of a transverse section through the eye reveals transcripts in the retinal ganglion cell layer and inner nuclear layer, but not in the pigmented epithelium, photoreceptor layer, ciliary marginal zone or lens. E: A hindbrain section showing signal in the IXth ganglion. e, eye; hb, hindbrain; inl, inner nuclear layer; le, lens; mb, midbrain; rgc, retinal ganglion cell layer; V, trigeminal; VII, facial nerve and geniculate; VIII, facial-acoustic; IX, glossopharyngeal; asterisks denote otic vesicle; brown pigment is seen in melanocytes and retinal pigmented epithelium.