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pmp22xenopus trigeminal ganglion 

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Experiment details for pmp22

Tae HJ et al. (2015) Assay

Temporal and spatial expression analysis of peripheral myelin protein 22 (Pmp22) in developing Xenopus.

Gene Clone Species Stages Anatomy
pmp22.L laevis NF stage 26 trigeminal ganglion
pmp22.L laevis NF stage 28 trigeminal ganglion

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  Fig. 2. Expression of Pmp22 in whole-mount in situ hybridization. (A) Expression of Pmp22 at stage 15 in the cement gland. Anterior view, dorsal to top. (B) At stage 22, Pmp22 was detected in the developing somites and profundal and trigeminal nerves. (C) At stage 22 Pmp22 sense probe was used as a negative control. (D) Pmp22 was expressed in the profundal and trigeminal ganglia, cranial mesenchyme, and somites at stage 29/30, where it was also beginning to be expressed in the branchial arches. (E) Strong expression of Pmp22 was observed in the craniofacial region. (F–G, I) To confirm the tissue-specific expression of Pmp22, we also performed in situ hybridization for Sox9 and Islet1. (H, I) At stage 35, both Pmp22 and Sox9 were detected in the branchial arches. Panels (B–I), lateral view, anterior to the left. ba, branchial arches; cg, cement gland; pr, profundal ganglia; s, somites; tg, trigeminal ganglia.

Gene Clone Species Stages Anatomy
pmp22.L laevis NF stage 29 and 30 trigeminal ganglion

  pmp22 (peripheral myelin protein 22) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 30, lateral view, anterior left, dorsal up.

Gene Clone Species Stages Anatomy
pmp22.L laevis NF stage 35 and 36 trigeminal ganglion
pmp22.L laevis NF stage 40 trigeminal ganglion

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  Fig. 3. Expression of Pmp22 determined by in situ hybridization of whole sections. (A) At stage 15, Pmp22 was weakly expressed in mesoderm cells. (B) At stage 30 Pmp22 sense probe was used as a negative control. (C–D) Transverse sections showing the expression of Pmp22 in the mesenchyme of the head at stage 35. Expression of Pmp22 was detected in the eye, craniofacial cartilage, trigeminal ganglia, and roof plate of the anterior neural tube, as well as floor plate of the posterior neural tube. (E) Schematic representation of the head of a stage 40 embryo as viewed from the lateral side, dorsal to top, and anterior to the left. Image was modified from Nieuwkoop and Faber (1967). (F–L) At stage 40, transverse sections revealed expression of Pmp22 in the head mesenchyme, floor plate of the developing brain, cartilage (F–I), lens (G), trigeminal ganglia (H), otic vesicle (I, L), developing trachea (J) and lungs (K). (L–O) At stage 40, expression of Pmp22 was observed in the dorsal (blue arrow) and ventral (green arrow) aspects of the developing otocyst. Islet1 (bracket) is expressed in the sensory organs of the otic vesicle (O), which did not overlap with Pmp22 (L). bc, basihyal cartilage; br, branchial cartilage; cc, craniofacial cartilage; ce, cerathoyal cartilage; di, diencephalon; et, ethmoid-trabecular cartilage; fp, floor plate; he, heart; le, lens; lu, lung; me, Meckel’s cartilage; no, notochord; ov, otic vesicle; ph, pharynx; qu, quadrate cartilage; rp, roof plate; st, stomodeum; tg, trigeminal ganglion; tr, trachea. The scale bar represents 100 μm.