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FIGURE 10. Dnmbp knockdown alters expression of late markers of kidney development, as assessed by in situ analysis. Embryos injected unilaterally at the 8-cell stage (blastomere V2) to target the kidney and reared to stage 40–41 for slc5a1, clcnkb, and atp1a1 expression assessment or stage 36–37 for nphs1 expression assessment. Representative embryo phenotypes shown. Scale bar indicates 500 μm. n = number of embryos across 2 (slc5a1, clcnkb, nphs1) or 3 replications (atp1a1). Error bars represent Standard error. ∗Significantly different from control, p < 0.05. |
