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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
casp3	xenopus		neuroectoderm [+] Mauthner cell,accessory olfactory bulb,adenohypophysis,amygdala,anterior amygdala,anterior commissure,anterior entopeduncular nucleus,anterior entopeduncular region,anterior hypothalamus,anterior neural fold,anterior neural tube,anterior tectum,anterior thalamic nucleus,anterodorsal tegmental nucleus,anteroventral tegmental nucleus,astrocyte,astrocyte end-foot,basal forebrain,basal ganglion,bed nucleus of the stria terminalis,brain ventricle,caudal tuberal region,cell body layer of the optic tectum,central amygdala,central nucleus of the thalamus,cerebellum,chordoneural hinge,diencephalon,dorsal column nucleus,dorsal habenular nucleus,dorsal pallidum,dorsal pallium,dorsal septum,dorsal tegmentum,dorsal telencephalon,dorsal thalamus,dorsolateral neural tube,eminentia thalami,external plexiform layer of the olfactory bulb,forebrain,forebrain-midbrain boundary,fourth ventricle,glomerular layer of the olfactory bulb,granule cell,granule cell layer of the cerebellum,granule cell layer of the olfactory bulb,habenula,hindbrain,hypophysis,hypothalamus,infundibulum,isthmic nucleus,lateral amygdala,lateral forebrain bundle,lateral ganglionic eminence,lateral hypothalamic nucleus,lateral pallium,lateral septum,laterodorsal tegmental nucleus,locus coeruleus,magnocellular preoptic nucleus,mammilary region,medial amygdala,medial ganglionic eminence,medial pallium,medial septum,medulla oblongata,melanotrope,mesencephalic artery,mesencephalic vein,metencephalic artery,metencephalic vein,midbrain,midbrain tegmentum,midbrain-hindbrain boundary,mitral cell,mitral cell layer of the olfactory bulb,neural stem cell,neurenteric canal,neurohypophysis,neuropil of the optic tectum,nucleus accumbens,nucleus of the diagonal band,nucleus of the solitary tract,nucleus reticularis inferior,nucleus reticularis medialis,nucleus reticularis superior,oculomotor motornucleus,olfactory bulb,oligodendrocyte,optic chiasm,optic stalk,optic tectum,optic tract,pallidum,pallium,pars distalis,pars intermedia,pars nervosa,pia mater,pial cell,pineal gland,posterior commissure,posterior hypothalamus,posterior neural fold,posterior neural tube,posterior tectum,posterior wall of neurenteric canal,posterodorsal tegmental nucleus,posteroventral tegmental nucleus,preoptic area,pretectum,prethalamus,prethalamus basal plate,prosomere,prosomere 4,prosomere 5,prosomere 6,radial glial cell,raphe nucleus,retromammillary area,rhombic lip,rhombomere,rostral tuberal region,solitary tract,stria terminalis,striatum,subcommissural organ,subpallium,subthalamic nucleus,sulcus limitans of neural tube,suprachiasmatic nucleus,supraoptoparaventricular region,telencephalon,telencephalon septum,thalamus,third ventricle,torus semicircularis,trochlear motornucleus,tuberal region,ventral habenular nucleus,ventral hypothalamic nucleus,ventral pallidum,ventral pallium,ventral septum,ventral tegmentum,ventricular layer of the optic tectum,ventricular zone,ventrolateral neural tube,ventrolateral thalamic nucleus,ventromedial thalamic nucleus,zona limitans intrathalamica,Jacobson's organ,anterior neural ridge,astrocyte,astrocyte end-foot,brain,choana,neural fold,neural groove,neural stem cell,neural tube,oculomotor motornucleus,olfactory nerve,olfactory organ,olfactory pit,olfactory placode,oligodendrocyte,radial glial cell

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Experiment details for casp3

Mcl1 protein levels and Caspase-7 executioner protease control axial organizer cells survival.

Mcl1 protein levels and Caspase-7 executioner protease control axial organizer cells survival.

Gene	Clone	Species	Stages	Anatomy
casp3.L		laevis	NF stage 13 to NF stage 14	neuroectoderm

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Figure 1: Endogenous apoptosis contributes to axial organizer formation independently of Caspase3 activity (A) TUNEL-staining reveals apoptosis in the axial midline. Representative TUNEL-stained wild type (wt) stage (st.) 12 Xenopus embryos. (B) Activated Caspase-3 (Act-Casp3) is not detected before stage 14 in Xenopus embryos. Representative immuno-staining against Act-Casp3 performed on st.10 to st.14 embryos. Act-Casp3 positive nuclei are shown with black arrows; st.10 to 12 ventral view dorsal up; st. 13 and 14 dorsal view anterior up. (C-F) Endogenous apoptosis affects establishment of the posterior neural plate via its activity on axial organizer signaling independently of Casp3. (C) Xenopus embryos were injected into one dorsal blastomere at the four-cell stage with mRNA encoding (a) X. laevis bcl-xl or (b) MOcasp3 together with a tracer (red) and analyzed by ISH with sox3. Representative st.14 embryos are shown. (c) Quantification graph of (a, b). (D) Xenopus embryos were injected into one dorsal blastomere at the four- (a), sixteen- (b, c) or thirty-two- (d) cells stage with mRNA encoding X. laevis bcl-xl or MOcasp3 together with a tracer (red) and analyzed by ISH with sox3. The site of injection (red dot), and the corresponding st.14 targeted territory (red area) are represented. The graph indicates the % of embryos exhibiting the (a-c) posterior, or (d) anterior, neural plate enlargement phenotype (blue). ML: medio-lateral; L: lateral; A: anterior neural plate. (E, F) Bcl-XL acts on the axial organizer cells. Embryos were injected either in the axial organizer (notochord and floor plate) or in lateral ectoderm with (E) bcl-xl or (F) MOcasp3. Representative embryos are shown dorsal view, anterior up, except (Fc) shown dorsal-anterior view. Representative transverse sections (50μm) are shown at the antero-posterior axis positions indicated with a white-dashed arrow (Eb,d; Fb,d). The black arrow indicates the limits of the injected territory. PNE: posterior neuroepithelium. Inj: injected side. White dashed lines indicate the midline. Relative normalized expression is indicated as means ± standard error (s.e.) *** p<0.001.