|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
foxa2
|
|
laevis
|
NF stage 32
|
spinal cord
,
endoderm
,
head endoderm
,
foregut
,
head
|
foxa2
|
|
laevis
|
NF stage 42
|
endoderm
,
trachea
,
esophagus
,
liver
,
foregut
,
[+]
|
sox2
|
|
laevis
|
NF stage 32
|
brain
,
endoderm
,
eye
,
foregut
,
head
,
[+]
|
sox2
|
|
laevis
|
NF stage 42
|
endoderm
,
trachea
,
foregut
,
lung primordium
|
sox2
|
|
laevis
|
NF stage 49
|
endoderm
,
trachea
,
esophagus
,
foregut
,
lung primordium
|
sox2
|
|
laevis
|
NF stage 59
|
lung primordium
|
nkx2-1
|
|
laevis
|
NF stage 33 and 34
|
brain
,
forebrain
,
endoderm
,
eye
,
foregut
,
[+]
|
nkx2-1
|
|
laevis
|
NF stage 42
|
endoderm
,
trachea
,
foregut
,
lung primordium
|
nkx2-1
|
|
laevis
|
NF stage 49
|
endoderm
,
trachea
,
foregut
,
lung primordium
|
nkx2-1
|
|
laevis
|
NF stage 59
|
endoderm
,
trachea
,
lung
,
foregut
,
lung primordium
|
shh
|
|
laevis
|
NF stage 32
|
brain
,
notochord
,
endoderm
,
pharyngeal arch
,
liver diverticulum
,
[+]
|
shh
|
|
laevis
|
NF stage 42
|
endoderm
,
foregut
,
lung primordium
,
liver primordium
|
shh
|
|
laevis
|
NF stage 49
|
endoderm
,
trachea
,
esophagus
,
stomach
,
foregut
,
[+]
|
shh
|
|
laevis
|
NF stage 59
|
trachea
,
lung
,
esophagus
|
sftpc
|
|
laevis
|
NF stage 37 and 38
|
endoderm
,
foregut
,
lung primordium
,
epithelial cell
|
sftpc
|
|
laevis
|
NF stage 42
|
endoderm
,
trachea
,
lung
,
foregut
,
epithelial cell
|
sftpc
|
|
laevis
|
NF stage 49
|
endoderm
,
trachea
,
lung
,
foregut
,
epithelial cell
|
sftpc
|
|
laevis
|
NF stage 59
|
endoderm
,
trachea
,
lung
,
foregut
,
epithelial cell
|
sox9
|
|
laevis
|
NF stage 35 and 36
|
brain
,
notochord
,
eye
,
head
,
pharyngeal region
|
sox9
|
|
laevis
|
NF stage 42
|
endoderm
,
foregut
,
lung primordium
|
sox9
|
|
laevis
|
NF stage 49
|
endoderm
,
trachea
,
lung
,
esophagus
,
foregut
|
sox9
|
|
laevis
|
NF stage 59
|
endoderm
,
trachea
,
lung
,
esophagus
,
foregut
|
|
|
Figure 3. Molecular characterization of the developing Xenopus foregut and respiratory epithelium. A: Schematic of the developing foregut region and respiratory system at the indicated developmental stages, with endoderm in yellow, heart (h) in orange, and respiratory epithelium in blue. B–Y: Whole-mount in situ hybridization with the indicated probes to whole embryos at NF32 (B,F,J), NF33 (N), NF35 (R), NF38 (V) or to isolated guts at NF42 (C,G,K,O,S,W) or to lung/tracheal/esophageal regions dissected at NF49 (D,H,L,P,T,X) or NF59 (E,I,M,Q,U,Y). Abbreviations: e, esophagus; fg, foregut; h, heart; lb, lung bud; lg, lung; lv, liver; st, stomach; tr, trachea; ty, thyroid. Scale bar = 0.5 mmDownload figure to PowerPoint |