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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
fzd3	xenopus		endomesoderm [+] Eberth-Kastschenko layer,Roux spot,abdominal myoblast,acinar cell,alpha cell,anterior dorsal lateral plate region,anterior endoderm,anterior foregut,anterior hindgut endoderm,anterior notochord,anterior palatine artery,anterior ventral blood island,antrum,archenteron,archenteron floor,archenteron roof midline,atrial septum,atrioventricular canal,atrioventricular canal endocardium,atrioventricular valve,atrioventricular valve leaflet,axial ossicle,beta cell,blastopore lip,capillary system of liver,cardia,cardiac atrium,cardiac jelly,cardiac myocyte,cardiac progenitor cell,cardiac valve,cardiac ventricle,caudal presomitic mesoderm,central endoderm,cerebral artery,chordoneural hinge,cloaca,cloacal sphincter,colon,cranial skeleton,delta cell,dermatome,dermomyotome,distal stomach,distal tubule,dorsal crest of the endoderm,dorsal endoderm,dorsal fin vasculature,dorsal foregut,dorsal lateral plate mesoderm,dorsal pancreatic bud,dorsal posterior hindgut endoderm,dorsomedial edge of myotome,duodenum,early distal tubule,early proximal tubule,endocardial cushion,endocardial tube,endocardium,endodermal cell,endothelial cell,enteric neuron,epicardial precursor cell,epicardium,epsilon cell,exocrine pancreas,external carotid artery,external coil of the small intestine,fasciculated network of fibrils,filter chamber,first pancreatic bud,flexural organ,foregut endoderm,foregut epithelium,fundus,gall bladder,gall bladder primordium,gamete,gamma cell,gastrocoel roof plate,germinal vesicle,glomeral nexus,glomerular epithelial cell,glomerular mesangial cell,glomerulus,glomus,head endoderm,head mesoderm,hematopoietic stem cell,hepato-pancreatic progenitor cell,hepatocyte,hindgut endoderm,hindgut primordium,hypochord,ileum,intermediate mesoderm,internal coil of the small intestine,intestinal stem cell,involuted dorsal mesoderm,involuted ventral mesoderm,islets of Langerhans,late distal tubule,late proximal tubule,lateral plate mesoderm,left atrium,left-right organizer,left-right organizer primordium,liver diverticulum,liver parenchyme,liver primordium,lower blastopore lip,lung bud,lung primordium,mandibular mesenchyme,mesodermal cell,mesonephric collecting duct,mesonephric tubule,midgut primordium,migrating macrophage,mitochondrial cloud,monociliated cell,myocardium,myocoelic slit,myotome,neurenteric canal,notochordal sheath,oocyte cortex,ooplasm,ophthalmic artery,outflow tract,paraxial mesoderm,pericardial muscle,pericardial roof,pericardium,perichordal tissue,pharyngeal endoderm,podocyte,post-anal gut,postcranial axial skeleton,posterior endoderm,posterior foregut,posterior hindgut endoderm,posterior notochord,posterior palatine artery,posterior ventral blood island,posterior wall of neurenteric canal,prechordal plate,presomitic mesoderm,presumptive paraxial mesoderm,pronephric duct,pronephric nephron,pronephric nephrostome,pronephric sinus,pronephric tubule,proximal stomach,proximal tubule,proximal tubule branch,pulmonary epithelium,pyloric sphincter,pylorus,rectal diverticulum,rectum,rib,right atrium,ring structure,rostral presomitic mesoderm,sclerotomal cartilage,sclerotomal mesenchyme,sclerotome,second pancreatic bud,sinus venosus,smooth muscle myocyte,somatic layer of lateral plate mesoderm,somite,spiral septum,splanchnic layer of lateral plate mesoderm,stomach,stomach body,stomach epithelium,stratum compactum,stratum spongiosum,sub-blastoporal endoderm,subcortical cytoplasm,suprablastoporal endoderm,syndetome,trabecula carnea,tracheoesophageal fold,tracheoesophageal septum,transient tracheoesophageal septum,transverse process,upper blastopore lip,urostyle,vacuolated notochordal tissue,vegetal cortex,vegetal endoderm,ventral blood island border,ventral endoderm,ventral fin vasculature,ventral foregut,ventral mesoderm,ventral posterior hindgut endoderm,ventricular outflow tract,ventrolateral edge of myotome,vertebra,vertebral centrum,vertebral column,vertebral element,wedge region,yolk platelet,Mullerian duct,anterior cardinal vein,anterior endoderm,anterior endomesoderm,anterior hindgut endoderm,anterior lymph sac,anterior palatine artery,aortic arch,archenteron,arteria iliaca communis,arteria mesenterica posterior,arteria subclavia,arterial endothelium,axial mesoderm,axial skeleton,bile duct,biliary tree,blastopore,buccopharyngeal membrane,capillary system of liver,cardiac atrium,cardiac mesoderm,cardinal vein,caudal artery,caudal vein,central endoderm,ceratobranchial I,ceratobranchial II,ceratobranchial III,ceratobranchial IV,cerebral artery,cervical vertebra,chondroblast,chondrocyte,circumblastoporal collar,cloacal sphincter,coeliaco-mesenteric artery,coelomic epithelium,commisura quadratocranialis anterior,cornua trabecula,cranial muscle,cranial muscle primordium,dermatome,dermis,dorsal aorta,dorsal endoderm,dorsal endomesoderm,dorsal fin vasculature,dorsal lymph space,dorsal pancreatic bud,dorsal posterior hindgut endoderm,duct of Cuvier,egg,elastica externa,endocardial tube,endocardium,endoderm,epicardium,erythroid cell,external carotid artery,external gill,external jugular vein,facies hyoidis of the palatoquadrate,fin vasculature,first pancreatic bud,flexural organ,foregut,foregut endoderm,foregut epithelium,gall bladder,gall bladder primordium,gastric vein,genital ridge,genital system,gill primordium,glomeral mesenchyme,glomeral nexus,glomus,head endoderm,head mesoderm,head somite 1,head somite 2,head somite 3,head somite 4,heart,heart primordium,hepatic portal vein,hepatic vein,hepato-pancreatic duct,hepato-pancreatic progenitor cell,hindgut,hindgut endoderm,hindgut primordium,hypochord,infrarostral,intermediate mesoderm,internal carotid artery,internal jugular vein,interrenal vein,intersomitic artery,intersomitic vein,intersomitic vessel,islets of Langerhans,kidney,large intestine,larval aorta,lateral plate mesoderm,lateral postcardinal vein,left channel of ventral aorta,left lymph heart,left spleen primordium,liver,liver diverticulum,liver parenchyme,liver primordium,lower blastopore lip,lung,lung bud,lung primordium,lymph vessel,m. cucullaris,m. depressor mandibulae,m. levator scapulae inferior,m. levator scapulae superior,m. petrohyoideus,medial abdominal vein,medial cardinal vein,mesenchymal stem cell,mesoderm,mesonephric duct,mesonephric early distal tubule,mesonephric early proximal tubule,mesonephric late distal tubule,mesonephric late proximal tubule,mesonephric mesenchyme,mesonephric nephron,mesonephric sinus,midgut,midgut primordium,musculoabdominal vein,myeloid cell,myocardium,myotome of head somite 1,myotome of head somite 2,myotome of head somite 3,myotome of head somite 4,myotome of tail somite 14,myotome of tail somite 15,myotome of tail somite 16,myotome of tail somite 17,myotome of tail somite 18,myotome of trunk somite 1,myotome of trunk somite 10,myotome of trunk somite 11,myotome of trunk somite 12,myotome of trunk somite 13,myotome of trunk somite 2,myotome of trunk somite 3,myotome of trunk somite 4,myotome of trunk somite 5,myotome of trunk somite 6,myotome of trunk somite 7,myotome of trunk somite 8,myotome of trunk somite 9,neurenteric canal,notochord,notochordal epithelium,occipitovertebral artery,omphalomesenteric vein,oocyte,oral evagination,oviduct,paired dorsal aorta,palatoquadrati,pancreas,parachordal,paraxial mesoderm,pharyngeal cavity,pharyngeal endoderm,pharyngeal pouch,planum hypobranchiale,planum trabeculare anticum,polar body,posterior cardinal vein,posterior endoderm,posterior endomesoderm,posterior hindgut endoderm,posterior vena cava,posterior ventral blood island,prechordal plate,presomitic mesoderm,presumptive paraxial mesoderm,primary heart field,primary oogonium,primary spermatogonium,primordial germ cell,processus anterior hyalis,processus articularis palatoquadrati,processus ascendens palatoquadrate,processus lateralis hyalis,processus muscularis palatoquadrati,processus posterior hyalis,processus retroarticularis of Meckel's cartilage,proctodeum,proepicardium,pronephric duct,pronephric kidney,pronephric mesenchyme,pronephric nephrostome,pronephric sinus,pulmonary vein,pyloric sphincter,right channel of ventral aorta,right lymph heart,right spleen primordium,sacral vertebra,sclerotome of head somite 4,sclerotome of tail somite 14,sclerotome of tail somite 15,sclerotome of tail somite 16,sclerotome of tail somite 17,sclerotome of tail somite 18,sclerotome of trunk somite 1,sclerotome of trunk somite 10,sclerotome of trunk somite 11,sclerotome of trunk somite 12,sclerotome of trunk somite 13,sclerotome of trunk somite 2,sclerotome of trunk somite 3,sclerotome of trunk somite 4,sclerotome of trunk somite 5,sclerotome of trunk somite 6,sclerotome of trunk somite 7,sclerotome of trunk somite 8,sclerotome of trunk somite 9,second pancreatic bud,secondary heart field,secondary oogonium,secondary spermatogonium,small intestine,smooth muscle,somatic layer of lateral plate mesoderm,somite,spermatid,spermatocyte,spermatozoon,spiral septum,splanchnic layer of lateral plate mesoderm,spleen,stomach,stomach epithelium,sub-blastoporal endoderm,subinterstitial vein,subocular cartilage,suprablastoporal endoderm,suprarostral plate,tail bud,tail somite 14,tail somite 15,tail somite 16,tail somite 17,tail somite 18,tail vein,taste bud,thyroid,thyroid primordium,trabecula carnea,trabecula cranii,trunk somite 1,trunk somite 10,trunk somite 11,trunk somite 12,trunk somite 13,trunk somite 2,trunk somite 3,trunk somite 4,trunk somite 5,trunk somite 6,trunk somite 7,trunk somite 8,trunk somite 9,urostyle,vascular endothelium,venous endothelium,ventral aorta,ventral blood island,ventral blood island border,ventral endoderm,ventral endomesoderm,ventral fin vasculature,ventral pancreatic bud,ventral posterior hindgut endoderm,visceral pouch

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Experiment details for fzd3

Frizzled 3 acts upstream of Alcam during embryonic eye development.

Frizzled 3 acts upstream of Alcam during embryonic eye development.

Gene	Clone	Species	Stages	Anatomy
fzd3.L		laevis	NF stage 28	intermediate mesoderm

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Fig. 1. Fzd3 loss of function results in an abnormal eye development. A. Spatial expression pattern of fzd3. Fzd3 transcripts are found in the neural tube (black arrowheads), migrating neural crest cells (white arrows) and the developing eye (white arrowheads) at indicated stages. B. Loss of Fzd3 led to smaller and deformed eyes on the injected side (white arrows) in comparison to the un-injected or Control MO injected side. Furthermore, Fzd3 inhibition resulted in disturbed retinal pigmented epithelium (RPE, red arrows). Representative embryos are shown. Scale bar (sections): 100 µm. C. Quantitative representation of the data shown in B. Note, that also the data from Fig. 5B are incorporated into the statistics. D. Detailed views of Fzd3 MO and Control MO injected eyes. Dashed red lines indicate measured eye areas. Red lines indicate the eye fissure angle (°fis.) measured. Quantitative representations of eye area and eye fissure angle (°fis.) measurements are given. E. Cross sections of Fzd3-depleted embryos after WMISH using marker genes against different retinal cell types. Loss of Fzd3 led to disorganized retinal cell layers including an invagination of the photoreceptor layer into inner retina layers (black arrows) and the formation of rosette-like structures by ectopic photoreceptor cells (red arrowheads). The ratios of Fzd3 MO injected embryos showing retinal lamination defects versus all investigated embryos are indicated. Scale bar: 100 µm. F. Lens specific markers celf1 and cryba1 are shown by WMISH. Marker gene expression was unaffected upon Fzd3 depletion although some lenses were smaller (the ratios of Fzd3 MO injected embryos showing smaller lenses versus all investigated embryos are indicated). Scale bar: 100 µm. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear cell layer; n, number of independent experiments; N, total number of analyzed embryos; ONL, outer nuclear cell layer; st, stage. Error bars indicate standard error of the mean (s.e.m.). **** p≤0.0001. p values were calculated by non-parametric Mann–Whitney rank sum test.