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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
nrxn1
|
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tropicalis
|
NF stage 32
|
retina
,
brain
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
nrxn2
|
|
laevis
|
NF stage 32
|
retina
,
brain
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
|
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Fig.4. Expression of α-neurexins is predominantly in neural tissue in
the tailbud embryo. (A,B) In situ hybridisation with a nrxn Iα probe
showing whole embryo (A) and an anterior neural section (B). Nrxn I is
found in cells along the length of the CNS but with a distinct gap at the
midbrain-hindbrain boundary. Sections show expression in the dorsolateral
neural tube and within the eye. (C,D) Embryos hybridised with a
nrxn IIα-specific probe show a similar pattern of staining to that seen with
nrxn I. (E,F) Embryos hybridised with a nrxn IIIα-specific probe show
much more restricted expression in the CNS and in section show ventrolateral
and eye expression in the anterior CNS (arrows). |
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Fig. 5 (Left). Nrxn III α is expressed in a subset of neural cells. (A,B) In
situ hybridisation with an α-nrxn III-specific probe identifies a row of
primary neurons at stage 24 (A), that lies either side of the midline towards
the anterior end of the embryo. (C) By the tailbud stage, expression
resolves into two stripes either side of the midline (red and green arrows).
Those arrowed in red are located in the position expected for primary
interneurons. The second band is located more ventrally. Within the head there are discrete areas of expression (yellow arrows). (D,E) Transverse
sections at the level of the hindbrain (D) and anterior spinal cord (E). nrxnIIIα expression (red arrows) is restricted to the lateral neural tube. |
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nrxn3 (neurexin 3) gene expression in Xenopus laevis embryo as assayed by in situ hybridization, NF stage 32. Lateral view: Dorsal up, anterior left. |