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Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
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snai1 | xenopus | epidermis [+] |
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Experiment details for snai1
KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis.KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis.
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Fig. S2 (related to Fig. 2). Assessment of the effects of KDM3A depletion on neural development. (A, B, C) Control (cMO) and KDM3A morphant (3A MO) embryos at stage 18in situ hybridized with indicated marker genes. (A) Neuronal genes. (B) Markers for neural progenitors (sox3, pax6) and the anteroposterior pattern (rx, krox20, en2, and hoxb9). (C) Markers for neural plate border, neural crest specification and epidermis. (D) Dorsal view of embryos at stage 18 showing that KDM3A depletion by injecting 60 ng 3A MO delays neural tube closure, which was partially rescued by injecting back of 500 pg the MO-resistant kdm3a mRNA. |