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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
zic3
|
|
laevis
|
NF stage 11.5
|
neural plate
,
anterior neural fold
|
zic3
|
|
laevis
|
NF stage 15
|
midbrain-hindbrain boundary
,
neural plate
|
zic3
|
|
laevis
|
NF stage 19
to
NF stage 23
|
central nervous system
,
lateral plate mesoderm
|
zic5
|
|
laevis
|
NF stage 11.5
|
anterior neural fold
|
zic5
|
|
laevis
|
NF stage 15
|
neuroectoderm
,
neural plate
|
zic5
|
|
laevis
|
NF stage 19
to
NF stage 23
|
eye
,
central nervous system
|
zic5
|
|
laevis
|
NF stage 23
|
roof plate
,
eye
,
neural fold
,
anterior neural ridge
|
zic5
|
|
laevis
|
NF stage 26
|
roof plate
,
eye
,
neural fold
,
anterior neural ridge
|
zic5
|
|
laevis
|
NF stage 33 and 34
|
retina
,
roof plate
,
neural fold
,
anterior neural ridge
|
zic1
|
|
laevis
|
NF stage 15
|
hyoid crest
,
branchial crest
,
neural crest
,
neural plate
,
cranial neural crest
|
zic1
|
|
laevis
|
NF stage 11.5
|
neural plate
,
anterior neural fold
|
zic1
|
|
laevis
|
NF stage 19
to
NF stage 23
|
somite
,
central nervous system
|
zic1
|
|
laevis
|
NF stage 26
|
brain
,
forebrain
,
midbrain
,
hindbrain
,
somite
|
zic1
|
|
laevis
|
NF stage 33 and 34
|
forebrain
,
midbrain
,
hindbrain
,
roof plate
,
somite
|
zic2
|
|
laevis
|
NF stage 11.5
|
anterior neural fold
|
zic2
|
|
laevis
|
NF stage 15
|
neural plate
|
zic2
|
|
laevis
|
NF stage 19
to
NF stage 23
|
eye
,
central nervous system
|
zic2
|
|
laevis
|
NF stage 26
|
roof plate
,
eye
,
anterior neural tube
,
neural tube
|
zic4
|
|
laevis
|
NF stage 11.5
|
anterior neural fold
|
zic4
|
|
laevis
|
NF stage 15
|
neural plate
|
zic4
|
|
laevis
|
NF stage 19
to
NF stage 23
|
olfactory placode
,
somite
,
central nervous system
|
zic4
|
|
laevis
|
NF stage 26
|
roof plate
,
anterior neural ridge
|
zic4
|
|
laevis
|
NF stage 33 and 34
|
roof plate
,
neural fold
,
anterior neural ridge
|
|
|
Figure 2. Expression profiles of Xenopus laevis Zic genes during embryonic development. Whole-mount in situ hybridization (WMISH) analyses with digoxigenin-labeled probes were performed to determine the spatial expression patterns of each Zic gene during development. Uppercase labels represent embryos stained with a Zic probe (A, Zic1; B, Zic2; C, Zic3; D, Zic4; E, Zic5). Lowercase labels indicate embryo stages (a, stage 11.5; b, 15; c, 19; d and e, 23; f, 26; g-i, 33). In b, arrows indicate the prospective region of hyoid crest and branchial crest, which have high Zic1 and Zic4 expression, and arrowheads show the anterior neural plate border region, with high levels of Zic5. e is the frontal view of the embryo shown in d. Arrowheads in d and e indicate the expression in eye (red), somite (green), lateral mesoderm (blue), and olfactory placode (white). h is a higher-magnification view of the embryo shown in g. i shows the transverse section of the WMISH sample of stage 33. The position of the section in i is indicated by a thin line in g. nt, neural tube; nc, notochord; ey, eye. |