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GEO Series: GSE53653

Title: Genome-wide view of TGFb/Foxh1 regulation of the early mesendoderm program [RNA-seq]

Summary

We identified Nodal and Foxh1 downstream targets by performing RNA-seq of embryos either treated with small molecule SB431542 or microinjected morpholino anti-sense oligo against Foxh1.


Contributors: William Chiu, William Chiu, Ken Cho

Experiment Type: Differential gene expression analyses of perturbed embryos (SB431542 treated, or Foxh1 MO injected) using RNA-seq

Experiment Reagents: Ethanol, foxh1 MO2, SB431542.

Article: Xenbase, PubMed

Source: NCBI GEO, Xenbase FTP

Samples: (DEG = Differentially Expressed Genes; GSM = GEO Sample Number)
Sample View GSMs Assay Type
WE - NF10.5 GSM1298097  RNA-Seq
Background: Xtr.Outbred
Conditions:
Tissue Assay Stages ChIP Antibody
embryo NF stage 10.5  
   WE + EtOH - NF10.5 DEG GSM1298095  RNA-Seq
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
chemical Ethanol NF stage 2 (2-cell) blastomere
Conditions:
Tissue Assay Stages ChIP Antibody
embryo NF stage 10.5  
   WE + SB431542 - NF10.5 DEG GSM1298096  RNA-Seq
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
chemical SB431542 NF stage 3 (4-cell) whole organism
Conditions:
Tissue Assay Stages ChIP Antibody
embryo NF stage 10.5  
   WE + foxh1 MO - NF10.5 DEG GSM1298098  RNA-Seq
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection foxh1 MO2 foxh1 NF stage 1 blastomere
Conditions:
Tissue Assay Stages ChIP Antibody
embryo NF stage 10.5  
Select All DEG      Select All 
Xtr   
Xla 

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